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1

Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub-Nanomolar SERCA Inhibition

Stephen P. Andrews, Matthew Ball, Frank Wierschem, Ed Cleator, Steven Oliver, Klemens Högenauer, Oliver Simic, Alessandra Antonello, Udo Hünger, Martin D. Smith, Steven V. Ley

Journal:

Chemistry - A European Journal

Année:

2007

Langue:

english

Fichier:

PDF, 512 KB

english, 2007

2

The Synthesis of Azadirachtin: A Potent Insect Antifeedant

Steven V. Ley, Antonio Abad-Somovilla, James C. Anderson, Carles Ayats, Rolf Bänteli, Edith Beckmann, Alistair Boyer, Maria G. Brasca, Abigail Brice, Howard B. Broughton, Brenda J. Burke, Ed Cleator,

Journal:

Chemistry - A European Journal

Année:

2008

Langue:

english

Fichier:

PDF, 596 KB

english, 2008

3

Asymmetric Synthesis of cis -2,5-Disubstituted Pyrrolidine, the Core Scaffold of β 3 -AR Agonists

Xu, Feng, Chung, John Y. L., Moore, Jeffery C., Liu, Zhuqing, Yoshikawa, Naoki, Hoerrner, R. Scott, Lee, Jaemoon, Royzen, Maksim, Cleator, Ed, Gibson, Andrew G., Dunn, Robert, Maloney, Kevin M., Alam,

Journal:

Organic Letters

Année:

2013

Langue:

english

Fichier:

PDF, 523 KB

english, 2013

4

Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)

Strotman, Neil A., Baxter, Carl A., Brands, Karel M. J., Cleator, Ed, Krska, Shane W., Reamer, Robert A., Wallace, Debra J., Wright, Timothy J.

Journal:

Journal of the American Chemical Society

Année:

2011

Langue:

english

Fichier:

PDF, 1.24 MB

english, 2011

5

Practical asymmetric synthesis of a CGRP receptor antagonist ubrogepant

Yasuda, Nobuyoshi, Cleator, Ed, Kosjek, Birgit, Yin, Jianguo, Xiang, Bangping, Chen, Frank, Kuo, Shen-Chun, Belyk, Kevin M., Mullens, Peter R, Goodyear, Adrian, Edwards, John S, Bishop, Brian, Ceglia,

Journal:

Organic Process Research & Development

Année:

2017

Langue:

english

Fichier:

PDF, 383 KB

english, 2017

6

Cover Picture: Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub-Nanomolar SERCA Inhibition (Chem. Eur. J. 20/2007)

Stephen P. Andrews, Matthew Ball, Frank Wierschem, Ed Cleator, Steven Oliver, Klemens Högenauer, Oliver Simic, Alessandra Antonello, Udo Hünger, Martin D. Smith, Steven V. Ley

Journal:

Chemistry - A European Journal

Année:

2007

Langue:

english

Fichier:

PDF, 387 KB

english, 2007

7

Cover Picture: The Synthesis of Azadirachtin: A Potent Insect Antifeedant (Chem. Eur. J. 34/2008)

Steven V. Ley, Antonio Abad-Somovilla, James C. Anderson, Carles Ayats, Rolf Bänteli, Edith Beckmann, Alistair Boyer, Maria G. Brasca, Abigail Brice, Howard B. Broughton, Brenda J. Burke, Ed Cleator,

Journal:

Chemistry - A European Journal

Année:

2008

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2008

8

ChemInform Abstract: The Synthesis of Chiral Polyhydroxylated Pyrrolidines Using a Reverse-Cope Cyclization.

Ian A. O'Neil, Ed Cleator, Neal Hone, J. Mike Southern, David J. Tapolczay

Journal:

Année:

2001

Fichier:

PDF, 28 KB

2001

9

ChemInform Abstract: The Stereospecific Addition of Hydroxylamines to α,β-Unsaturated Sulfones, Nitriles and Nitro Compounds.

Ian A. O'Neil, Ed Cleator, J. Mike Southern, Jamie F. Bickley, David J. Tapolczay

Journal:

Année:

2002

Fichier:

PDF, 33 KB

2002

10

ChemInform Abstract: A Convenient Synthesis of Secondary Hydroxylamines.

Ian A. O'Neil, Ed Cleator, David J. Tapolczay

Journal:

Année:

2002

Fichier:

PDF, 28 KB

2002

11

A Rapid Stereocontrolled Synthesis of the 3a-Hydroxy-pyrrolo[2,3-b]indole Skeleton, a Building Block for 10b-Hydroxypyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones.

Steven V. Ley, Ed Cleator, Peter R. Hewitt

Journal:

Année:

2004

Fichier:

PDF, 152 KB

2004

12

Synthesis of (-)-Gloeosporone, a Fungal Autoinhibitor of Spore Germination Using a π-Allyltricarbonyliron Lactone Complex as a Templating Architecture for 1,7-Diol Construction.

Steven V. Ley, Ed Cleator, Juergen Harter, Christopher J. Hollowood

Journal:

Année:

2004

Fichier:

PDF, 69 KB

2004

13

The Synthesis of (-)-Gloeosporone, a Potent Fungal Autoinhibitor of Spore Germination Using a π-Allyltricarbonylation Lactone Complex and a New Reductive Decomplexation Procedure for the Installation of the Embedded 1,7-Diol Component of the Natural Product.

Ed Cleator, Juergen Harter, Steven V. Ley

Journal:

Année:

2004

Fichier:

PDF, 63 KB

2004

14

Grignard Additions to 2-Uloses: Synthesis of Stereochemically Pure Tertiary Alcohols.

Ed Cleator, Catherine F. McCusker, Frank Steltzer, Steven V. Ley

Journal:

Année:

2004

Fichier:

PDF, 159 KB

2004

15

The Diastereoselective Synthesis of Functionalized Isoxazolidines Using a Cope Elimination/Intramolecular Nitrone Cycloaddition Strategy.

Ian A. O'Neil, V. Elena Ramos, Gemma L. Ellis, Ed Cleator, Alan P. Chorlton, David J. Tapolczay, S. Barret Kalindjian

Journal:

Année:

2004

Fichier:

PDF, 84 KB

2004

16

The Synthesis of Chiral Functionalized Morpholine N-Oxides Using a Tandem Cope Elimination/Reverse-Cope Elimination Protocol.

Ian A. O'Neil, Ed Cleator, V. Elena Ramos, Alan P. Chorlton, David J. Tapolczay

Journal:

Année:

2004

Fichier:

PDF, 99 KB

2004

17

A Concise Total Synthesis of (+)-Okaramine C.

Peter R. Hewitt, Ed Cleator, Steven V. Ley

Journal:

Année:

2005

Fichier:

PDF, 11 KB

2005

18

ChemInform Abstract: A Mild and Efficient One-Pot Synthesis of 2-Aminated Benzoxazoles and Benzothiazoles.

Gavin W. Stewart, Carl A. Baxter, Ed Cleator, Faye J. Sheen

Journal:

Année:

2009

Fichier:

PDF, 32 KB

2009

19

ChemInform Abstract: Regioselective Coupling Reactions of 2,4-Diaminopyridine Derivatives with Aryl Halides: The Synthesis of Elaborated Pyridines.

Matthew M. Bio, Ed Cleator, Antony J. Davies, Simon E. Hamilton, Andrew Lawrence, Faye J. Sheen, Gavin W. Stewart, Robert D. Wilson

Journal:

Année:

2010

Fichier:

PDF, 43 KB

2010

20

ChemInform Abstract: Synthesis of Novel Benzoxathiazepine-1,1-dioxides by Means of a One-Pot Multicomponent Reaction.

Ed Cleator, Carl A. Baxter, Michael O'Hagan, Timothy J. C. O'Riordan, Faye J. Sheen, Gavin W. Stewart

Journal:

Année:

2010

Fichier:

PDF, 46 KB

2010

21

ChemInform Abstract: A Novel Approach to 3-Methylindoles by a Heck/Cyclization/Isomerization Process.

Carl A. Baxter, Ed Cleator, Mahbub Alam, Antony J. Davies, Adrian Goodyear, Michael O'Hagan

Journal:

Année:

2010

Fichier:

PDF, 31 KB

2010

22

ChemInform Abstract: Total Synthesis of (-)-Nakadomarin A.

Andrew F. Kyle, Pavol Jakubec, Dane M. Cockfield, Ed Cleator, John Skidmore, Darren J. Dixon

Journal:

Année:

2012

Fichier:

PDF, 35 KB

2012

23

ChemInform Abstract: Enantio- and Diastereoselective Michael Additions of C-Succinimidyl Esters to Nitro Olefins Using Cinchonine-Derived Bifunctional Organocatalysts.

Pavol Jakubec, Dane M. Cockfield, Peter S. Hynes, Ed Cleator, Darren J. Dixon

Journal:

Année:

2012

Fichier:

PDF, 37 KB

2012

24

Regioselective coupling reactions of 2,4-diaminopyridine derivatives with aryl halides: the synthesis of elaborated pyridines

Matthew M. Bio, Ed Cleator, Antony J. Davies, Simon E. Hamilton, Andrew Lawrence, Faye J. Sheen, Gavin W. Stewart, Robert D. Wilson

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 434 KB

english, 2009

25

Grignard additions to 2-uloses: synthesis of stereochemically pure tertiary alcohols

Ed Cleator, Catherine F. McCusker, Frank Steltzer, Steven V. Ley

Journal:

Tetrahedron Letters

Année:

2004

Langue:

english

Fichier:

PDF, 260 KB

english, 2004

26

The synthesis of chiral functionalised morpholine N-oxides using a tandem Cope elimination/reverse-Cope elimination protocol

Ian A O'Neil, Ed Cleator, V Elena Ramos, Alan P Chorlton, David J Tapolczay

Journal:

Tetrahedron Letters

Année:

2004

Langue:

english

Fichier:

PDF, 244 KB

english, 2004

27

The diastereoselective synthesis of functionalised isoxazolidines using a Cope elimination/intramolecular nitrone cycloaddition strategy

Ian A O'Neil, V.Elena Ramos, Gemma L Ellis, Ed Cleator, Alan P Chorlton, David J Tapolczay, S.Barret Kalindjian

Journal:

Tetrahedron Letters

Année:

2004

Langue:

english

Fichier:

PDF, 250 KB

english, 2004

28

Regioselective synthesis of N-substituted-4-substituted isothiazolidine-1,1-dioxides

Ed Cleator, Faye J. Sheen, Matthew M. Bio, K.M. Jos Brands, Antony J. Davies, Ulf-H. Dolling

Journal:

Tetrahedron Letters

Année:

2006

Langue:

english

Fichier:

PDF, 99 KB

english, 2006

29

The synthesis of functionalised chiral bicyclic lactam and lactone N-oxides using a tandem Cope elimination/reverse Cope elimination protocol

Gemma L. Ellis, Ian A. O’Neil, V. Elena Ramos, Ed Cleator, S. Barret Kalindjian, Alan P. Chorlton, David J. Tapolczay

Journal:

Tetrahedron Letters

Année:

2007

Langue:

english

Fichier:

PDF, 147 KB

english, 2007

30

Synthesis of novel benzoxathiazepine-1,1-dioxides by means of a one-pot multicomponent reaction

Ed Cleator, Carl A. Baxter, Michael O’Hagan, Timothy J.C. O’Riordan, Faye J. Sheen, Gavin W. Stewart

Journal:

Tetrahedron Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2010

31

A convenient synthesis of secondary hydroxylamines

Ian A O'Neil, Ed Cleator, David J Tapolczay

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 95 KB

english, 2001

32

The stereospecific addition of hydroxylamines to α,β-unsaturated sulfones, nitriles and nitro compounds

Ian A O'Neil, Ed Cleator, J.Mike Southern, Jamie F Bickley, David J Tapolczay

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 141 KB

english, 2001

33

Development of a Scaleable Synthesis of a Partial Nicotinic Acid Receptor Agonist

Wilson, Robert D., Cleator, Ed, Ashwood, Michael S., Bio, Matthew M., Brands, Karel M. J., Davies, Antony J., Dolling, Ulf-H., Emerson, Khateeta M., Gibb, Andrew D., Hands, David

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 497 KB

english, 2009

34

Process Development and Large-Scale Synthesis of MK-6186, a Non-Nucleoside Reverse Transcriptase Inhibitor for the Treatment of HIV

Goodyear, Adrian, Linghu, Xin, Bishop, Brian, Chen, Cheng, Cleator, Ed, McLaughlin, Mark, Sheen, Faye J., Stewart, Gavin W., Xu, Yingju, Yin., Jingjun

Journal:

Organic Process Research & Development

Année:

2012

Langue:

english

Fichier:

PDF, 395 KB

english, 2012

35

Development of a Robust Procedure for the Copper-catalyzed Ring-Opening of Epoxides with Grignard Reagents

Alam, Mahbub, Wise, Christopher, Baxter, Carl A., Cleator, Ed, Walkinshaw, Andrew

Journal:

Organic Process Research & Development

Année:

2012

Langue:

english

Fichier:

PDF, 2.93 MB

english, 2012

36

Route Development and Multikilogram GMP Delivery of a Somatostatin Receptor Antagonist

Ruck, Rebecca T., Huffman, Mark A., Stewart, Gavin W., Cleator, Ed, Kandur, Wynne V., Kim, Mary M., Zhao, Dalian

Journal:

Organic Process Research & Development

Année:

2012

Langue:

english

Fichier:

PDF, 663 KB

english, 2012

37

Enantio- and diastereoselective Michael additions of C-succinimidyl esters to nitro olefins using cinchonine-derived bifunctional organocatalysts

Pavol Jakubec, Dane M. Cockfield, Peter S. Hynes, Ed Cleator, Darren J. Dixon

Journal:

Tetrahedron: Asymmetry

Année:

2011

Langue:

english

Fichier:

PDF, 526 KB

english, 2011

38

A concise total synthesis of (+)-okaramine C

Hewitt, Peter R., Cleator, Ed, Ley, Steven V.

Journal:

Organic & Biomolecular Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 271 KB

english, 2004

39

The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder

Baxter, Carl A., Cleator, Ed, Brands, Karel M. J., Edwards, John S., Reamer, Robert A., Sheen, Faye J., Stewart, Gavin W., Strotman, Neil A., Wallace, Debra J.

Journal:

Organic Process Research & Development

Année:

2011

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2011

40

A Mild and Efficient One-Pot Synthesis of 2-Aminated Benzoxazoles and Benzothiazoles

Stewart, Gavin W., Baxter, Carl A., Cleator, Ed, Sheen, Faye J.

Journal:

Journal of Organic Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 125 KB

english, 2009

41

Total Synthesis of Thapsigargin, a Potent SERCA Pump Inhibitor

Ball, Matthew, Andrews, Stephen P., Wierschem, Frank, Cleator, Ed, Smith, Martin D., Ley, Steven V.

Journal:

Organic Letters

Année:

2007

Langue:

english

Fichier:

PDF, 120 KB

english, 2007

42

Synthesis of (?)-Gloeosporone, a fungal autoinhibitor of spore germination using a ?-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol constructionElectronic supplementary information (ESI) available: experimental procedure and data for 7. See http://www.rsc.org/suppdata/ob/b3/b308793j/

Ley, Steven V., Cleator, Ed, Harter, J�rgen, Hollowood, Christopher J.

Journal:

Organic & Biomolecular Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 97 KB

english, 2003

43

Process Development and Multikilogram-Scale Synthesis of a TRPV1 Antagonist

Cleator, Ed, Scott, Jeremy P., Avalle, Paulo, Bio, Matthew M., Brewer, Sarah E., Davies, Antony J., Gibb, Andrew D., Sheen, Faye J., Stewart, Gavin W., Wallace, Debra J., Wilson., Robert D.

Journal:

Organic Process Research & Development

Année:

2013

Langue:

english

Fichier:

PDF, 370 KB

english, 2013

44

Enantioselective Synthesis of a Highly Substituted Tetrahydrofluorene Derivative as a Potent and Selective Estrogen Receptor Beta Agonist

Maddess, Matthew L., Scott, Jeremy P., Alorati, Anthony, Baxter, Carl, Bremeyer, Nadine, Brewer, Sarah, Campos, Kevin, Cleator, Ed, Dieguez-Vazquez, Alejandro, Gibb, Andrew, Gibson, Andrew, Howard, Me

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 769 KB

english, 2014

45

Total synthesis of (−)-nakadomarin A

Kyle, Andrew F., Jakubec, Pavol, Cockfield, Dane M., Cleator, Ed, Skidmore, John, Dixon, Darren J.

Journal:

Chemical Communications

Année:

2011

Langue:

english

Fichier:

PDF, 677 KB

english, 2011

46

A Novel Approach to 3-Methylindoles by a Heck/Cyclization/Isomerization Process

Baxter, Carl A., Cleator, Ed, Alam, Mahbub, Davies, Antony J., Goodyear, Adrian, O’Hagan, Michael

Journal:

Organic Letters

Année:

2010

Langue:

english

Fichier:

PDF, 363 KB

english, 2010

47

Intramolecular Cyclopropanation of Unsaturated Terminal Epoxides and Chlorohydrins

Hodgson, David M., Chung, Ying Kit, Nuzzo, Irene, Freixas, Glòria, Kulikiewicz, Krystyna K., Cleator, Ed, Paris, Jean-Marc

Journal:

Journal of the American Chemical Society

Année:

2007

Langue:

english

Fichier:

PDF, 149 KB

english, 2007

48

A Practical and Scaleable Synthesis of 1 R ,5 S -Bicyclo[3.1.0]hexan-2-one: The Development of a Catalytic Lithium 2,2,6,6-Tetramethylpiperidide (LTMP) Mediated Intramolecular Cyclopropanation of ( R )-1,2-Epoxyhex-5-ene

Alorati, Anthony D., Bio, Matthew M., Brands, Karel M. J., Cleator, Ed, Davies, Antony J., Wilson, Robert D., Wise, Chris S.

Journal:

Organic Process Research & Development

Année:

2007

Langue:

english

Fichier:

PDF, 57 KB

english, 2007

49

A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxy-pyrazino[1?,2?:1,5]pyrrolo[2,3-b]indole-1,4-diones

Ley, Steven V., Cleator, Ed, Hewitt, Peter R.

Journal:

Organic & Biomolecular Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 145 KB

english, 2003

50

A Synthesis of a Spirocyclic Macrocyclic Protease Inhibitor for the Treatment of Hepatitis C

Chung, Cheol K., Cleator, Ed, Dumas, Aaron M., Hicks, Jacqueline D., Humphrey, Guy R., Maligres, Peter E., Nolting, Andrew F., Rivera, Nelo, Ruck, Rebecca T., Shevlin, Michael

Journal:

Organic Letters

Année:

2016

Langue:

english

Fichier:

PDF, 529 KB

english, 2016